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Comparison of Pharmacokinetic models for DCE-MRI
Bačovská, Kristýna ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This thesis deals with perfusion analysis using DCE-MRI (Dynamic contrast-enhanced magnetic resonance imaging). DCE-MRI is commonly used for microcirculation evaluation mainly in oncology and in recent years also in cardiology. The theoretical overview focuses on the issue of pharmacokinetic modeling and the estimation of perfusion parameters using selected models. The experimental part describes research software PerfLab and then it is aimed at the proposed program for synthetic data generation. Simulated data obtained under ideal conditions and in the presence of noise were used to compare models for the accuracy and reliability of DCE-MRI analysis.
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Framework for Data Generators
Kříž, Blažej ; Ráb, Jaroslav (referee) ; Zendulka, Jaroslav (advisor)
This master's thesis is focused on the problem of data generation. At the beginning, it presents several applications for data generation and describes the data generation process. Then it deals with development of framework for data generators and demonstrational application for validating the framework.
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Image-Based Clustering of Microbial Colonies
Láncoš, Jan ; Kišš, Martin (referee) ; Beneš, Karel (advisor)
Laboratorní analýza mikrobiálních kolonií pěstovaných na Petriho miskách je v současné době předmětem intenzivního výzkumu ve snaze o dosažení totální laboratorní automatizace. Jádro tohoto problému spočívá v přesné lokalizaci kolonií při obrazové analýze. Současná řešení nejčastěji využívají strojové učení, které je však obecně závislé na kvalitních datech, kterých je v tomto odvětví k dispozici jen velmi málo. Abych adresoval tento problém, vytvořil jsem víceúčelový generátor syntetických dat. Úspěšně jsem jej aplikoval jak při segmentaci tak při shlukování kolonií. Výsledné segmentační F1 skóre se mi podařilo navýšit z 0,518 na 0,729 a při shlukování jsem s využitím této segmentace dosáhl V-measure skóre 0,830. Prací navržený přístup ke generování syntetických dat nás posouvá o krok blíže k plné laboratorní automatizaci.
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Comparison of Pharmacokinetic models for DCE-MRI
Bačovská, Kristýna ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This thesis deals with perfusion analysis using DCE-MRI (Dynamic contrast-enhanced magnetic resonance imaging). DCE-MRI is commonly used for microcirculation evaluation mainly in oncology and in recent years also in cardiology. The theoretical overview focuses on the issue of pharmacokinetic modeling and the estimation of perfusion parameters using selected models. The experimental part describes research software PerfLab and then it is aimed at the proposed program for synthetic data generation. Simulated data obtained under ideal conditions and in the presence of noise were used to compare models for the accuracy and reliability of DCE-MRI analysis.
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Polarization analysis of strong ground motions recorded during the aftershock sequence of the 2009 L'Aquila earthquake
Čejka, František ; Gallovič, František (advisor) ; Zahradník, Jiří (referee)
During broadband modelling of selected events from the aftershock sequence of the l'Aquila earthquake using 1-D model of media, we observe interesting difference between model and real particle polarization on high frequencies. There are two basic types of these polarization disorders. Polarization of particle motion keeps its linear form, but changes its direction or linear polarization changes its linear form to circle polarization. It offers the explanation that these disorders of polarization occur due to the 3D heterogeneities in the crust. In this work, we analyze polarization of published synthetic seismograms modeled with random 3D heterogenitites. It has been shown that the biggest disorders occur in directions in which parcticle movement heads toward the source, and that we can find examples, which qualitatively explain observed polarization disorders.
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Framework for Data Generators
Kříž, Blažej ; Ráb, Jaroslav (referee) ; Zendulka, Jaroslav (advisor)
This master's thesis is focused on the problem of data generation. At the beginning, it presents several applications for data generation and describes the data generation process. Then it deals with development of framework for data generators and demonstrational application for validating the framework.
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